Metabolomics investigation reveals metabolic mediators associated with <i>Ligusticum wallichii</i>-relieving experimental acute pancreatitis

Background: Acute pancreatitis (AP) is a typical destructive inflammation of the pancreas. The direct effect L. wallichii on AP remains unknown.Methods: animal model was constructed by intraperitoneal injection caerulein in male Sprague–Dawley rats. extracts were used to treat rats with AP. Then, tissue injury evaluated hematoxylin and eosin staining. Serum indicators, including amylase, lipase, KL-6, creatinine urea, measured commercial kits. GC/MS-based metabolomics utilized characterize metabolome.Results: Intraperitoneal protected against lung, liver, kidney caerulein-induced analysis revealed that treatment could restore alteration abundance most metabolites. These differential metabolites enriched twelve metabolic pathways able be reprogramed administration. impacted arginine metabolism inhibiting arginase expression activity. Inhibition S-(2-boronoethyl)-L-cysteine (BEC) relieve AP, suggesting suppression potential mechanism for ameliorate AP.Conclusion: Our data provide inter-relationship between reprograming anti-AP effects rats, highlight pathogenesis.